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KMID : 1035320150420030217
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Korean Society for Dental Materials
2015 Volume.42 No. 3 p.217 ~ p.227
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Porous Hydroxyapatite for Sustained Drug Release
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Seo Ki-Won
Kang Dong-Ho
Ko Yeong-Mu
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Abstract
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Sustained drug release of hollow HA was investigated. HA slurry was prepared with amount of 30-70% HA(H groups) and sodium chloride up to 15%(N groups). Alginate beads were coated with HA slurry and burned out. In order to insert vancomycin-laden PLGA nanoparticles into hollow HA granules, vacuum pressure was applied. Drug release rates of vancomycin from HA/PLGA complex were monitored. Size of HA spherical granules was controlled by injecting size or dropping speed into liquid nitrogen. Internal empty space that formed by burning out alginate beads during sintering was connected to external surface through pores in the shell. In H groups, increasing the ratio between HA and water, thickness of shell was increased, while the pore size and porosity was decreased because pores were formed as water frozen and subsequent sublimation of ice inside the shell. Addition of sodium chloride did not affect pore size and porosity in N groups. However, irregular-shaped pores were caused because sodium chloride that remains after the lyophilization burns out during the sintering. This played a role in delay the initial burst out of the drug. In conclusion, tailoring the structure of pore channels between internal space and external surface was the key to control the sustained drug release rate.
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KEYWORD
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Bone-graft, Bone regeneration, Drug delivery, Hydroxyapatite, PLGA, Vancomycin
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